He has had solo exhibitions in Madrid, Naples, Milan, Rome, Berlin, Basel, Bern, London, Frankfurt, Stuttgart and in collective exhibitions at the 54th Venice Biennale, MoMA PS1 (New York), the Stedelijk Museum (Amsterdam), at SMAK (Ghent), Kaiserdome Frankfurt, the Kunstmuseum in Bonn (Germany), at the Fukuyama Museum of Art (Japan), the Modern Art Gallery of Bologna (Italy), the MART in Trento and Rovereto (Italy).
His works was exhibited alongside those of Caravaggio in the Cerasi Chapel in Santa Maria del Popolo in Rome during the 56 th Venice Biennale he presented at Giorgio Cini Foundation (Island of San Giorgio Maggiore) “Stabat Mater Dolorosa” with the soundtrack of Ennio Morricone made for the artwork.
Giovanni Manfredini is represented by Henze Ketterer, Bern and Basel, Switzerland.